2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1896
    Piperaquine
    		Inhibitor
    Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin.
    Piperaquine
  • HY-113607
    Asimicin
    		Inhibitor
    Asimicin (Bullatacin) is antitumor acetogenin that can be isolated from the bark and seeds of the pawpaw tree, Asimina trilobal Dunal. Asimicin inhibits mitochondrial respiration through the inhibition of complex I. Asimicin shows toxicity to Aphis gossypii, mosquito larvae and mammalian.
    Asimicin
  • HY-101725
    Meclonazepam
    		Inhibitor 99.10%
    Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect. Meclonazepam is active against immature S. mansoni. Meclonazepam (30 μM) eliminates 100% of immature parasites. Meclonazepam has a anti-schistosomal effect.
    Meclonazepam
  • HY-146042
    Antiparasitic agent-4
    		Inhibitor
    Antiparasitic agent-4 (compound 4q) has highly antiparasitic activity against Leishmania infantum (L. infantum) and Trypanosoma cruzi (T. cruzi) with IC50s of 8.51 μM and 2.20 μM, respectively. Antiparasitic agent-4 also has certain cytotoxicity against HepG2 (CC50 = 18.97 μM).
    Antiparasitic agent-4
  • HY-149289
    DNMT-IN-3
    		Inhibitor
    DNMT-IN-3 is an DNA Methyltransferase (DNMT) inhibitor, and plays an antimalarial role with IC50 of 60 nM against Plasmodium falciparum (Plasmodium). DNMT-IN-3 can be used for malaria related research.
    DNMT-IN-3
  • HY-P10215
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2
    		Inhibitor
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively.
    Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2
  • HY-172206
    TSO-13
    		Inhibitor
    TSO-13 is the inhibitor for the main cysteine protease of Trypanosoma cruzi Cruzipain with an IC50 of 2.2 μM. TSO-13 inhibits T. cruzi in Vero cell with an IC50 of 1.9 μM.
    TSO-13
  • HY-B1064R
    Clindamycin phosphate (Standard)
    		Inhibitor
    Clindamycin phosphate (Standard) is the analytical standard of Clindamycin phosphate. This product is intended for research and analytical applications. Clindamycin phosphate (Clindamycin 2-phosphate) is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate is the proagent of Clindamycin (HY-B1455) with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate can be used for researching acne and bacterial vaginosis.
    Clindamycin phosphate (Standard)
  • HY-D1532
    DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS
    DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite.
    DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS
  • HY-149960
    Antiparasitic agent-17
    		Inhibitor
    Antiparasitic agent-17 (compound 5u) is an orally active antiparasitic agent. Antiparasitic agent-17 inhibits Chloroquine sensitive (Pf3D7) and Chloroquine resistant (PfK1) strain with IC50s of 0.96 μM and 1.67 μM, respectively.
    Antiparasitic agent-17
  • HY-A0163CR
    trans-Clopenthixol dihydrochloride (Standard)
    		Inhibitor
    trans-Clopenthixol (dihydrochloride) (Standard) is the analytical standard of trans-Clopenthixol (dihydrochloride). This product is intended for research and analytical applications. trans-Clopenthixol ((E)-Clopenthixol) dihydrochloride is an antibiotic agent, without neuroleptic effect. trans-Clopenthixol can be used to inhibit Pseudomonas aeruginosa and Plasmodium falciparum in vitro[1][2].
    trans-Clopenthixol dihydrochloride (Standard)
  • HY-146043
    Antiparasitic agent-5
    		Inhibitor
    Antiparasitic agent-5 (compound 8h) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an IC50 value of 2.50 μM. Antiparasitic agent-5 also has certain cytotoxicity against HepG2 (CC50 = 6.78 μM).
    Antiparasitic agent-5
  • HY-130993
    Isatropolone A
    		Inhibitor
    Isatropolone A, a natural product containing a 1,5-diketone moiety, is reisolated from Streptomyces Gö66. Isatropolone A shows potent activity against Leishmania donovani with an IC50 of 0.5 μM.
    Isatropolone A
  • HY-138050
    Nyasol
    		Inhibitor
    Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells.
    Nyasol
  • HY-127087
    Isogarcinol
    		Inhibitor
    Isogarcinol (Cambogin) is a potent AChE and BChE inhibitor, with IC50 values of 1.13 and 8.30 μM, respectively. Isogarcinol also shows leishmanicidal activity, with an IC50 of 0.33 μM against L. donovani.
    Isogarcinol
  • HY-116535A
    DL-threo-PPMP hydrochloride
    DL-threo-PPMP hydrochloride is an inhibitor of sphingosine synthetase in Plasmodium falciparum. DL-threo-PPMP hydrochloride inhibits the activity of sphingosine synthetase (sphingosine synthetase) by binding to a substrate that mimics sphingosine. This inhibition leads to a rapid decline in sensitive sphingomyelin synthase (SSS) activity, selectively disrupting the interconnected tubular network of TVM in the cytoplasm of the host cell, and this inhibition also blocks the proliferation of the parasite. DL-threo-PPMP hydrochloride can be used in the study of malaria parasite biology and the search for new antimalarial strategies.
    DL-threo-PPMP hydrochloride
  • HY-17598S
    Rafoxanide-13C6
    		Inhibitor
    Rafoxanide 13C6 is a labeled Rafoxanide (HY-17598). Rafoxanide is a salicylanilide used as an antiparasitic agent[1].
    Rafoxanide-<sup>13</sup>C<sub>6</sub>
  • HY-143409
    Antimalarial agent 10
    Antimalarial agent 10 (Compound 17b) is an aminoalcohol quinoline compound. Antimalarial agent 10 is an antimalarial agent with IC50 values of 14.9 nM and 11.0 nM against respectively Pf3D7 and PfW2 and a selectivity index higher than 770 whatever the cell line is.
    Antimalarial agent 10
  • HY-17598R
    Rafoxanide (Standard)
    		Inhibitor
    Rafoxanide (Standard) is the analytical standard of Rafoxanide. This product is intended for research and analytical applications. Rafoxanide is a poent, orally active halogenated salicylaniline agent with antiparasitic activity. Rafoxanide interferes with energy metabolism in trematodes by uncoupling oxidative phosphorylation. Rafoxanide is also found to be a potent inhibitor of the BRAF V600E mutant protein, which is important in colorectal cancer. Rafoxanide can be used for the control of infestation with Hemonchus species or Fasciola species in sheep and cattle as well as Oestrus ovis in sheep. Rafoxanide can also be used for cancer research.
    Rafoxanide (Standard)
  • HY-B1198R
    Piperonyl butoxide (Standard)
    		Inhibitor
    Piperonyl butoxide (Standard) is the analytical standard of Piperonyl butoxide. This product is intended for research and analytical applications. Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice.
    Piperonyl butoxide (Standard)
Parasite Isoform Comparison

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